Reversible Signal Binding by the Pseudomonas aeruginosa Quorum-Sensing Signal Receptor LasR
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منابع مشابه
Reversible Signal Binding by the Pseudomonas aeruginosa Quorum-Sensing Signal Receptor LasR
Many members of the LuxR family of acyl-homoserine lactone (acyl-HSL)-dependent quorum-sensing transcriptional activators are thought to have the unusual characteristics of requiring the signal ligand during polypeptide synthesis to fold into an active conformation and of binding signal extraordinarily tightly. This is the case for the N-3-oxo-dodecanoyl-HSL-dependent Pseudomonas aeruginosa vir...
متن کاملQuorum-Sensing Regulator LasR in Pseudomonas aeruginosa
± Current Address: Department of Microbiology, University of Washington School of 21 Medicine, 1959 NE Pacific St., Room K-360, Seattle, WA 98195-7242. 22 23 ね Current address: Department of Molecular, Cellular and Developmental Biology, 24 219 Prospect St., Yale University, New Haven, CT 06471 25 26 * Corresponding author. Mailing address: Department of Molecular, Cellular and 27 Developmental...
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The primary quorum sensing system in the opportunistic pathogen Pseudomonas aeruginosa is regulated through the synthesis and secretion of N-3-oxo-dodecanoyl-L-homoserine lactone (C12) which binds the transcriptional activator LasR. In this study we report the design, synthesis and biological evaluation of new analogs of C12. Analysis of the autoinducer binding site cavity of LasR revealed a po...
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Along with their cognate acyl-homoserine lactone signals, the quorum sensing regulators LasR and RhlR control the expression of hundreds of genes in the opportunistic human pathogen Pseudomonas aeruginosa. This extensive, overlapping regulatory network affords the opportunity to systematically investigate the sequence requirements and specificity determinants of large families of target promote...
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Pseudomonas aeruginosa pathogenic potential is controlled via multiple regulatory pathways, including three quorum sensing (QS) systems. LasR is a key QS signal receptor since it acts as a global transcriptional regulator required for optimal expression of main virulence factors. P. aeruginosa modulates the QS response by integrating this cell density-dependent circuit to environmental and meta...
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ژورنال
عنوان ژورنال: mBio
سال: 2011
ISSN: 2161-2129,2150-7511
DOI: 10.1128/mbio.00011-11